![]() Tueller provides design and analysis leadership for several ongoing multisite randomized trials, hybrid trials, idiographic clinical trials, and implementation studies in research areas spanning child welfare, juvenile justice, human trafficking, rare diseases, HIV services, adult criminal justice, and addiction. Stephen Tueller is a Senior Research Statistician in the Division of Applied Justice Research at RTI International. This research was supported by funding from the National Center for Advancing Translational Sciences (R21TR002402, principal investigator Ridenour).ĭr. General recommendations for designing idiographic clinical trials are drawn from the Monte Carlo simulations. The motivating contexts and examples to illustrate idiographic clinical trials are prevention science and treatments for rare diseases. PersonAlyticsPower is illustrated with results from a recent series of Monte Carlo simulations which explored the impact of multiple study design factors on statistical power to detect treatment effects such as sample size, number of repeated observations, and number of observations per study phase. ![]() Finally, the newly developed PersonAlyticsPower R package for a priori power analyses to plan study designs is presented. This presentation briefly reviews idiographic clinical trials, their strengths and limitations, and recent advances in these methodologies. This has led to recent fundamental advances and spurred a resurgence in using these methods. Coupling within-subject experimental designs with rigorous statistical analysis, referred to as idiographic clinical trials, overcomes many historical limitations of within-subject designs. ![]() Within-subject clinical trials have long been considered an inferior option to randomized clinical trials in psychology and medicine even though they can address critical research questions that randomized trials cannot. ![]()
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